The versatile wood of Pacific dogwood is heavy and hard. Due to its workability and strength, the wood has historically been used for everything from bows and arrows to thread spindles, and even golf clubs. The wood is still in considerable demand, yet its collection is prohibited in British Columbia, where the flower is the province's floral emblem. The bark of Pacific dogwood was used for a number of medicinal purposes by Native American peoples of the region, and was used by early frontiersmen as a substitute for quinine to cure malaria.

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